The development of vaccines plays a crucial role in global health, yet the ability of developing countries to develop their vaccines remains limited. This comprehensive article explores the multifaceted challenges faced by developing nations in vaccine development, incorporating data, statistics, and references from relevant studies. By examining the barriers related to research and development infrastructure, technology transfer, intellectual property rights, regulatory systems, manufacturing capacities, and funding, this article provides a comprehensive analysis of why the developing world faces difficulties in achieving self-sufficiency in vaccine development.